Post-infection transitory partial correction of thrombocytopenia in may-hegglin anomaly

May-Hegglin anomaly.

A 35-year-old woman with known May-Hegglin anomaly (and a positive family history) was seen in a fertility clinic. She was found to have marked thrombocytopenia (16 109/L). The other cell counts were normal. Other than hypothyroidism that was controlled with levothyroxine, she was otherwise healthy with no evidence of bleeding. The peripheral blood film demonstrated the features of May-Hegglin ...

Ultrastructural Studies of the May-Hegglin Anomaly

By S. W. JORDAN AND \V. E. LARSEN I HE INHERITED CONDITION known as the May-Hegghin anomaly is characterized by the occurrence of crescent or spindle-shaped cytoplasmic inclusions containing ribose nucleic acid ( RNA ) in polymorphonuclear leukocytes in combination with platelet abnormalities. May ( 1909) 1 noted the presence of distinctive basophilic, pyroninophilic patches in the cytoplasm of...

Ultrastructure of the May-Hegglin anomaly.

Ultrastructural features of the leucocytes in two patients suffering from the May-Hegglin anomaly were studied using electron microscopy. In both the cases, electron dense material parallel to the long axis of the inclusions were noted. Platelet ultrastructure was normal. A review of the literature indicates that the May-Hegglin anomaly is a heterogeneous condition both ultrastructurally and cl...

Ultrastructural Studies of the May-hegglin Anomaly.

A rare familial thrombocytopenia: May-Hegglin anomaly report of two cases and review of the literature.

May-Hegglin anomaly is a hereditary thrombocytopenia associated with giant platelets and large basophilic, cytoplasmic inclusion bodies (resembling Döhle bodies) in the granulocytes. Patients may experience easy bruising, recurrent epistaxis, gingival bleeding, menorrhagia and sometimes excessive bleeding associated with surgical procedures. Failure to appropriately diagnose May-Hegglin anomaly...